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Symbol
Name
ID

Gfap
glial fibrillary acidic protein
MGI:95697

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Increased CSF protein concentration

Spasticity

Diffuse demyelination of the cerebral white matter

Hydrocephalus

Abnormal dentate nucleus morphology

Ataxia

Dysmetria

Palatal tremor

Babinski sign

Dysarthria

Apathy

Drowsiness

Bulbar signs

Developmental regression

Seizure

Disease(s) Associated with GFAP

Alexander disease

Mouse Phenotypes

nervous system phenotype

increased susceptibility to pharmacologically induced seizures

abnormal blood-brain barrier function

abnormal brain iron level

non-obstructive hydrocephaly

abnormal brain white matter morphology

decreased corpus callosum size

abnormal CNS glial cell morphology

abnormal astrocyte morphology

abnormal oligodendrocyte morphology

gliosis

abnormal oligodendrocyte physiology

abnormal myelination

abnormal excitatory postsynaptic potential

enhanced long-term potentiation

reduced long-term depression

Availability

Mouse Genotype

Gfap^tm1Ito/Gfap^tm1Ito

*

Gfap^tm1Ldtk/Gfap^tm1Ldtk

Gfap^tm1Mes/Gfap^tm1Mes

Gfap^tm1Pkny/Gfap^tm1Pkny

*

Gfap^tm2Ito/Gfap^tm2Ito

*

Gfap^tm2Mes/Gfap^tm2Mes

Gfap^tm3Ito/Gfap^tm3Ito

Gfap^tm3Mes/Gfap^tm3Mes

Gfap^tm4Ito/Gfap^tm4Ito

Gfap^tm2Mes/Gfap⁺

Gfap^tm3Mes/Gfap⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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